DelveInsight launched a new report on Parkinson’s Disease Pipeline Insights, 2020
Some of the key facts of the report:-
Some pharmaceutical and biotech companies like Prevail Therapeutics, Axovant Gene Therapies, Neurocrine Biosciences/Voyager Therapeutics, Denali Therapeutics, and others are researching new therapies that target other aspects of pathology, namely genetic mutations, and Lewy bodies (a hallmark feature of Parkinson’s disease).
Apart from these, other small molecule that are under development and expected to enter the market includes Istradefylline (Kyowa Kirin), Opicapone (Neurocrine Biosciences), P2B001 (Pharma Two B Ltd), LY03003 (Luye Pharma), ABBV-951 (AbbVie), APL-130277 (Sunovion Pharma), Accordion Pill (Intec Pharma), Apomorphine infusion (US WorldMeds LLC), IPX203 (Impax Laboratories), IRL752 (Integrative Research Laboratories AB), ND0612 (NeuroDerm), ITI-214 (Intra-Cellular Therapies), Nilotinib (Novartis), etc. The expected launch of these therapies during the forecasted period are expected to impact the market size of Parkinson’s Disease (PD) in the upcoming years.
Neurocrine Biosciences is developing a new gene therapy VY-AADC, which is currently being evaluated in patients who have been diagnosed with Parkinson’s disease for at least 4 years, are not responding adequately to oral medications, and have at least 3 hours of “off” time during the day, as measured by a validated self-reported patient diary. It is developed by Neurocrine Biosciences and Voyager Therapeutics as part of strategic collaboration.
Istradefylline (Nouriast) is a selective agonist at the A2A receptor that is administered orally. It reduces dyskinesia resulting from long-term treatment with classical anti-parkinson drugs such as levodopa. The drug is already approved in Japan in 2013, and the company has filed a new drug application for its approval in the US.
Opicapone (Ongentys) is a new long-acting, peripherally selective, once- daily catechol-O-methyl transferase inhibitor. Opicapone is licensed in Europe for the treatment of Parkinson’s disease. Neurocrine has filed an application for its approval in the US.
P2B001 is a low-dose, sustained release combination of pramipexole and resagiline. This new approach takes advantage of the well-known therapeutic effects and good safety profile of both Parkinson’s drugs and combines it with Pharma Two B’s proprietary sustained-release formulation. The company believes that P2B001 has the potential to become a leading therapy for early stage PD and claims that once approved, it is expected to provide early-stage Parkinson’s patients with effective treatment with an improved safety profile.
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Scope of the Report
Report highlights
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Table of contents
1. Report Introduction
2. Parkinson’s Disease
2.1. Overview
2.2. History
2.3. Parkinson’s Disease Symptoms
2.4. Causes
2.5.Pathophysiology
2.6. Parkinson’s Disease Diagnosis
2.6.1. Diagnostic Guidelines
3. Parkinson’s Disease Current Treatment Patterns
3.1. Parkinson’s Disease Treatment Guidelines
4. Parkinson’s Disease – DelveInsight’s Analytical Perspective
4.1. In-depth Commercial Assessment
4.1.1. Parkinson’s Disease companies collaborations, Licensing, Acquisition -Deal Value Trends
4.1.1.1. Assessment Summary
4.1.2. Parkinson’s Disease Collaboration Deals
4.1.2.1. Company-Company Collaborations (Licensing / Partnering) Analysis
4.1.2.2. Company-University Collaborations (Licensing / Partnering) Analysis
4.1.2.3. Parkinson’s Disease Acquisition Analysis
5. Therapeutic Assessment
5.1. Clinical Assessment of Pipeline Drugs
5.1.1. Assessment by Phase of Development
5.1.2. Assessment by Product Type (Mono / Combination)
5.1.2.1. Assessment by Stage and Product Type
5.1.3. Assessment by Route of Administration
5.1.3.1. Assessment by Stage and Route of Administration
5.1.4. Assessment by Molecule Type
5.1.4.1. Assessment by Stage and Molecule Type
5.1.5. Assessment by MOA
5.1.5.1. Assessment by Stage and MOA
5.1.6. Assessment by Target
5.1.6.1. Assessment by Stage and Target
6. Parkinson’s Disease Late Stage Products (Phase-III)
7. Parkinson’s Disease Mid Stage Products (Phase-II)
8. Early Stage Products (Phase-I)
9. Pre-clinical Products and Discovery Stage Products
10. Inactive Products
11. Dormant Products
12. Parkinson’s Disease Discontinued Products
13. Parkinson’s Disease Product Profiles
13.1. Drug Name: Company
13.1.1. Product Description
13.1.1.1. Product Overview
13.1.1.2. Mechanism of action
13.1.2. Research and Development
13.1.2.1. Clinical Studies
13.1.3. Product Development Activities
13.1.3.1. Collaboration
13.1.3.2. Agreements
13.1.3.3. Acquisition
13.1.3.4. Patent Detail
13.1.4. Tabulated Product Summary
13.1.4.1. General Description Table
14. Parkinson’s Disease Key Companies
15. Parkinson’s Disease Key Products
16. Dormant and Discontinued Products
16.1. Dormant Products
16.1.1. Reasons for being dormant
16.2. Discontinued Products
16.2.1. Reasons for the discontinuation
17. Parkinson’s Disease Unmet Needs
18. Parkinson’s Disease Future Perspectives
19. Parkinson’s Disease Analyst Review
20. Appendix
21. Report Methodology
21.1. Secondary Research
21.2. Expert Panel Validation
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